FARMAKOTERAPI DEPRESI DAN PENGARUH JENIS KELAMIN TERHADAP EFIKASI ANTIDEPRESAN

AJENG RATNA NINGTYAS, Irma Melyani Puspitasari, Rano Kurnia Sinuraya

Abstract


Depresi merupakan penyakit yang berhubungan dengan alam perasaan yang sedih dan gejala penyerta berupa perubahan pola tidur dan nafus makan, psikomotor, konsentrasi, anhedonia, kelelahan, rasa putus asa, dan tidak berdaya serta bunuh diri. Menurut WHO, terdapat 322 juta orang penderita depresi. Depresi menjadi penyebab utama bunuh diri yaitu 800.000 per tahun. Pengobatan depresi dengan menggunakan obat antidepresan. Review artikel ini bertujuan untuk mengetahui farmakoterapi yang tepat untuk mengobati depresi dan mengetahui pengaruh jenis kelamin terhadap efikasi antidepresan. Metode yang digunakan dalam review artikel ini adalah studi literature. Studi literature dilakukan dengan cara mencari jurnal, e-book, dan situs web yang membahas tentang farmakoterapi depresi dan pengaruh jenis kelamin terhadap efikasi antidepresan. Kriteria tahun penerbitan yang dikumpulkan adalah 10 tahun terakhir. Dari hasil studi literature didapatkan 17 jurnal, 5 e-book, dan 1 situs web. Dari studi yang telah dilakukan dapat disimpulkan bahwa farmakoterapi depresi yang paling sering digunakan dan lini pertama adalah SSRI dan SNRI. Terdapat pengaruh jenis kelamin terhadap efikasi antidepresan.

Kata Kunci: Depresi, Pengobatan, Farmakoterapi, Antidepresan


References


Lumis, Namora L. 2009. Depresi: Tinjauan Psikologis. Jakarta: Kencana.

Nolen-Hoeksema S. 1990. Sex Differences in Depression. California: Stanford University Press

Harlow BL, Wise LA, Otto MW, Soares CN, Cohen LS. 2003. Depression and its influence on reproductive endocrine and menstrual cycle markers associated with perimenopause: The Harvard Study of Mood and Cycle. Arch Gen Psychiatry. 60(1): 29-36

Moreno FA, McGahuey CA, Freeman MP, Delgado PL. 2006. Sex differences in depressive response during monoamine depletions in remitted depressive subject. J Clin Psychiatry. 67(10): 1618-1623.

Sadock, B. J. & Sadock, V. A., 2010. Buku Ajar Psikiatri Klinis Edisi 2. Jakarta: Penerbit Buku Kedokteran EGC.

Olfson M. Marcus SC., Druss B., et al. 2002. National Trends in the Outpatient Treatment of Depression. JAMA. 287: 203-209

Paulose-Ram R., Safran MA., Jonas Bs., et al. 2007. Trends in Psychotropic Medication Use Among U.S Adults. Pharmacoepidemiol Drug Saf. 16: 560-570

Isacsson G., Boethius G., Henriksson S., et al. 1999. Selective Serotonin Reuptake Inhibitors Have Broadened the Utilisation of Antidepressant Treatment in Accordance with recommendation. Findings from a Swedish Prescription Data Base. J Affect Discord. 53:15-22.

Yerkade & Siddiqui. 2017. A Drug Utilization Study of Antidepressant Drug in A Tertiary Care Hospital. International Journal of Basic & Clinical Pharmacology. 6(6): 1405-1409.

American Psychiatric Association. 2018. What is depression.

Available at https://www.psychiatry.org/patients-families/depression/what-is-depression

Kessler and Evelyn. 2013. The Epidemiology of Depression Across Cultures. Annu Rev Public Health. 34: 119-138.

Kanter JW., Busch AM, Weeks CE., et al. 2008. The Nature of Clinical Depression: Symptoms, Syndromes, and Behavior Analysis. Behav Anal. 31(1):1-21.

NICE. 2010. Depression: The Treatment and Management of Depression in Adult. Leicester: National Collaborating Centre for Mental Health.

Nutt DJ., Jonathan RT., Alan JG., Higuchi T et al. 2010. International Consensus Statement On major Depressive Disorder. J Clin Psychiatry. 71(Suppl E1): e08.

Young EA., Kornstein SG., Marcum SM., et al. 2009. Sex differences in response to citalopram: a STAR*D report. J Psychiatry Res. 43(5): 503-511.

Yang SJ, Kim SY, Stewart R., et al. 2011. Gender differences in 12-week antidepressant treatment outcomes for a naturalistic secondary care cohort: the CRESCEND study. Psychiatry Res. 189(1): 82-90.

Kornstein SG., Clyaton Ah., Soares CN., Padmanabhan SK., Guico-Pabia Ch. 2010. Analysis by age and sex of efficacy data form placebo-controlled trials of desvenlafaxine in outpatients with major depressive disorder. J Clin Psychopharmacol. 30(3): 294-299.

Kornstein SG., Pedersen RD, Holland PJ., et al. 2014. Influence of sex and menopausal status on response, remmissio, and reccurence in patient with reccurent amhor depressive disoreder treated with venlafaxine extended release or fluoxetine: analysis of data fom the PREVENT study. J Clin Psychiatry. 75(1):62-68.

Cuijpers P., Weitz E., Twisk J., et al. 2014. Gender as predictor and moderator of outcome in cognitive behaviour therapy and pharmacotherapy for adult depression: an individual patient data meta analysis. Depress Anxiety. 31(11):941-951.

Tsai SJ., Gau YT., Hong CJ., et al. 2009. Sexually dimorphic effect of catechol-O-methyltransferase val158 met polymorphism on clinical response to fluoxetine in major depressive patient. J affect Disord. 113:183-187.

Morishita S., Kinoshita T. 2008. Predictors of response to sertraline in patients with major depression. Hum Psychopharmacol. 23: 647-651.

Wolfe SM. 2008. SSRI can have dangerous interaction with other drugs. Worst Pils Best Pills News. 14(1): 2-5.

Kauffman. 2009. Selective Serotonin Reuptake Inhibitor (SSRI) Drugs: More Risks than Benefits?. Journal of American Physicians and Surgeons. 14(1): 2009.

Santarsieri and Schwartz. 2014. Antidepressant efficacy and side-effect burden: a quick guide for clinicians. Drugs Context. 4:212290.

Sansone and Sansone. 2014. Serotonin Norepinephrine Reuptake inhibitor: A Pharmacological Comparison. Innov Clin Neurosci. 11(3-4): 37-42.

Dziwota and Olajossy. 2016. Vortioxetine – The new antidepressant agent with precognitive properties. Acta Pol Pharm. 73(6): 1433-1437.

McClintock. 2011. A Systematic Review of the Combined Use of Electroconvulsive Therapy and Psychotherapy for Depression. Journal ECT. 27(3): 236-243.

Lisanby SH., Sampson S, Husain MM, et al. 2008. Toward Individualized post-electroconvulsive therapy care: piloting the symptom-titrated, algorithm-based longitudinal (STABLE) intervention. J ECT. 24(3): 179-182.

Tjay, T. H. & Rahardja, K., 2010. Obat Obat Penting. Jakarta: Elex Media Komputindo.

Carek PJ., Laibstain SE., Cark SM. Exercise for the treatment of depression and anxiety. Int J Psychiatry Med. 41(1): 15-28.

Katzung, B. G., Masters, S. B. & Trevor, A. J., 2012. Basic & Clinical Pharmacology 12th Edition. USA: The Mc Graw Hill.

Wells, B. G., Dipiro, J. T., Schwinghammer, T. L. & Dipiro, C. V., 2009. Pharmacotherapy Handbook Seventh Edition.New York: The McGraw-Hill Companies.

Veral A., Alper G., Mentes G., Ersoz B. 1997. Age and sec related alterations in serum and platelet monoamine oxidase. Eur J Clin Chem Clin Biochem. 35(4): 265-268.

Moreno FA., McGahuey CA., Freeman MP., Delgado PL. 2006. Sex differences in depressive response during monoamine depletion in remitted depressive subject. J Clin Psychiatry. 67(10): 1618-1623.

Adams et al. 2008. Pharmacologic Management of Adult Depression. American Family Physician 77(6):785-792.

Suzuki et al. 2015. Screening for Major Depressive Disorder with the Patient Health Questionnaire (PHQ-9 dan PHQ-2) in an Outpatient Clinic Staffed by Primary Care Physicians in Japan: A Case Control Study. Journal PLOS One. 10(3)

DAFTAR PUSTAKA

Lumis, Namora L. 2009. Depresi: Tinjauan Psikologis. Jakarta: Kencana.

Nolen-Hoeksema S. 1990. Sex Differences in Depression. California: Stanford University Press

Harlow BL, Wise LA, Otto MW, Soares CN, Cohen LS. 2003. Depression and its influence on reproductive endocrine and menstrual cycle markers associated with perimenopause: The Harvard Study of Mood and Cycle. Arch Gen Psychiatry. 60(1): 29-36

Moreno FA, McGahuey CA, Freeman MP, Delgado PL. 2006. Sex differences in depressive response during monoamine depletions in remitted depressive subject. J Clin Psychiatry. 67(10): 1618-1623.

Sadock, B. J. & Sadock, V. A., 2010. Buku Ajar Psikiatri Klinis Edisi 2. Jakarta: Penerbit Buku Kedokteran EGC.

Olfson M. Marcus SC., Druss B., et al. 2002. National Trends in the Outpatient Treatment of Depression. JAMA. 287: 203-209

Paulose-Ram R., Safran MA., Jonas Bs., et al. 2007. Trends in Psychotropic Medication Use Among U.S Adults. Pharmacoepidemiol Drug Saf. 16: 560-570

Isacsson G., Boethius G., Henriksson S., et al. 1999. Selective Serotonin Reuptake Inhibitors Have Broadened the Utilisation of Antidepressant Treatment in Accordance with recommendation. Findings from a Swedish Prescription Data Base. J Affect Discord. 53:15-22.

Yerkade & Siddiqui. 2017. A Drug Utilization Study of Antidepressant Drug in A Tertiary Care Hospital. International Journal of Basic & Clinical Pharmacology. 6(6): 1405-1409.

American Psychiatric Association. 2018. What is depression.

Available at https://www.psychiatry.org/patients-families/depression/what-is-depression

Kessler and Evelyn. 2013. The Epidemiology of Depression Across Cultures. Annu Rev Public Health. 34: 119-138.

Kanter JW., Busch AM, Weeks CE., et al. 2008. The Nature of Clinical Depression: Symptoms, Syndromes, and Behavior Analysis. Behav Anal. 31(1):1-21.

NICE. 2010. Depression: The Treatment and Management of Depression in Adult. Leicester: National Collaborating Centre for Mental Health.

Nutt DJ., Jonathan RT., Alan JG., Higuchi T et al. 2010. International Consensus Statement On major Depressive Disorder. J Clin Psychiatry. 71(Suppl E1): e08.

Young EA., Kornstein SG., Marcum SM., et al. 2009. Sex differences in response to citalopram: a STAR*D report. J Psychiatry Res. 43(5): 503-511.

Yang SJ, Kim SY, Stewart R., et al. 2011. Gender differences in 12-week antidepressant treatment outcomes for a naturalistic secondary care cohort: the CRESCEND study. Psychiatry Res. 189(1): 82-90.

Kornstein SG., Clyaton Ah., Soares CN., Padmanabhan SK., Guico-Pabia Ch. 2010. Analysis by age and sex of efficacy data form placebo-controlled trials of desvenlafaxine in outpatients with major depressive disorder. J Clin Psychopharmacol. 30(3): 294-299.

Kornstein SG., Pedersen RD, Holland PJ., et al. 2014. Influence of sex and menopausal status on response, remmissio, and reccurence in patient with reccurent amhor depressive disoreder treated with venlafaxine extended release or fluoxetine: analysis of data fom the PREVENT study. J Clin Psychiatry. 75(1):62-68.

Cuijpers P., Weitz E., Twisk J., et al. 2014. Gender as predictor and moderator of outcome in cognitive behaviour therapy and pharmacotherapy for adult depression: an individual patient data meta analysis. Depress Anxiety. 31(11):941-951.

Tsai SJ., Gau YT., Hong CJ., et al. 2009. Sexually dimorphic effect of catechol-O-methyltransferase val158 met polymorphism on clinical response to fluoxetine in major depressive patient. J affect Disord. 113:183-187.

Morishita S., Kinoshita T. 2008. Predictors of response to sertraline in patients with major depression. Hum Psychopharmacol. 23: 647-651.

Wolfe SM. 2008. SSRI can have dangerous interaction with other drugs. Worst Pils Best Pills News. 14(1): 2-5.

Kauffman. 2009. Selective Serotonin Reuptake Inhibitor (SSRI) Drugs: More Risks than Benefits?. Journal of American Physicians and Surgeons. 14(1): 2009.

Santarsieri and Schwartz. 2014. Antidepressant efficacy and side-effect burden: a quick guide for clinicians. Drugs Context. 4:212290.

Sansone and Sansone. 2014. Serotonin Norepinephrine Reuptake inhibitor: A Pharmacological Comparison. Innov Clin Neurosci. 11(3-4): 37-42.

Dziwota and Olajossy. 2016. Vortioxetine – The new antidepressant agent with precognitive properties. Acta Pol Pharm. 73(6): 1433-1437.

McClintock. 2011. A Systematic Review of the Combined Use of Electroconvulsive Therapy and Psychotherapy for Depression. Journal ECT. 27(3): 236-243.

Lisanby SH., Sampson S, Husain MM, et al. 2008. Toward Individualized post-electroconvulsive therapy care: piloting the symptom-titrated, algorithm-based longitudinal (STABLE) intervention. J ECT. 24(3): 179-182.

Tjay, T. H. & Rahardja, K., 2010. Obat Obat Penting. Jakarta: Elex Media Komputindo.

Carek PJ., Laibstain SE., Cark SM. Exercise for the treatment of depression and anxiety. Int J Psychiatry Med. 41(1): 15-28.

Katzung, B. G., Masters, S. B. & Trevor, A. J., 2012. Basic & Clinical Pharmacology 12th Edition. USA: The Mc Graw Hill.

Wells, B. G., Dipiro, J. T., Schwinghammer, T. L. & Dipiro, C. V., 2009. Pharmacotherapy Handbook Seventh Edition.New York: The McGraw-Hill Companies.

Veral A., Alper G., Mentes G., Ersoz B. 1997. Age and sec related alterations in serum and platelet monoamine oxidase. Eur J Clin Chem Clin Biochem. 35(4): 265-268.

Moreno FA., McGahuey CA., Freeman MP., Delgado PL. 2006. Sex differences in depressive response during monoamine depletion in remitted depressive subject. J Clin Psychiatry. 67(10): 1618-1623.

Adams et al. 2008. Pharmacologic Management of Adult Depression. American Family Physician 77(6):785-792.

Suzuki et al. 2015. Screening for Major Depressive Disorder with the Patient Health Questionnaire (PHQ-9 dan PHQ-2) in an Outpatient Clinic Staffed by Primary Care Physicians in Japan: A Case Control Study. Journal PLOS One. 10(3)




DOI: https://doi.org/10.24198/jf.v16i2.17522

DOI (PDF (Bahasa Indonesia)): https://doi.org/10.24198/jf.v16i2.17522.g8755

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Copyright (c) 2018 AJENG RATNA NINGTYAS, Irma Melyani Puspitasari, Rano Kurnia Sinuraya