KANDUNGAN SENYAWA KIMIA MURBEI HITAM (Morus nigra L.) DAN EFEK FARMAKOLOGINYA

NADIATUL KHAIRA. Y, ZELIKA MEGA RAMADHANIA

Abstract


Murbei hitam (Morus nigra L.) adalah salah satu tanaman yang banyak dimanfaatkan sebagai obat. Tanaman ini tersebar luas di berbagai negara yang beriklim subtropis. Variasi konsumsi dari buah ini pun juga beragam mulai dari buah segar, buah kering, jus buah, dan minuman beralkohol. Murbei hitam memiliki banyak manfaat sebagai pengobatan berbagai penyakit seperti diabetes mellitus, radang, iritasi tenggorokan, kerusakan pada gigi, dan anemia. Hal ini disebabkan karena kandungan senyawa bioaktif dalam tanaman ini yang cukup banyak, dimana didominasi oleh senyawa turunan fenolik. Senyawa bioaktif inilah yang memberikan kontribusi terhadap berbagai aktivitas yang dihasilkan oleh tanaman murbei hitam ini.

References


Abbas, G. M. et al. (2014) ‘A new antioxidant stilbene and other constituents from the stem bark of Morus nigra L.’, Natural Product Research, 28(13), pp. 952–959. doi: 10.1080/14786419.2014.900770.

Abbasi, A. M. et al. (2013) ‘Ethnobotanical survey of medicinally important wild edible fruits species used by tribal communities of Lesser Himalayas-Pakistan’, Journal of Ethnopharmacology. Elsevier, 148(2), pp. 528–536. doi: 10.1016/j.jep.2013.04.050.

Akkol, E. K. et al. (2015) ‘Bioassay-guided isolation and characterization of wound healer compounds from morus nigra l. (moraceae)’, Records of Natural Products, 9(4), pp. 484–495. Available at: http://www.scopus.com/inward/record.url?eid=2-s2.0-84930652153&partnerID=tZOtx3y1.

Aljane, F. and Sdiri, N. (2016) ‘Morphological, Phytochemical and Antioxidant Characteristics of White (Morus alba L.), Red (Morus rubra L.) and Black (Morus nigra L.) Mulberry Fruits Grown in Arid Regions of Tunisia’, Journal of new sciences Agriculture and Biotechnology, 35(351), pp. 1940–1947.

Arshad, M. A. et al. (2014) ‘Ethnobotanical and taxonomic screening of genus Morus for wild edible fruits used by the inhabitants of Lesser Himalayas-Pakistan’, Journal of Medicinal Plants Research, 8(25), pp. 889–898. doi: 10.5897/JMPR2010.733.

Ercisli, S. and Orhan, E. (2008) ‘Some physico-chemical characteristics of black mulberry (Morus nigra L.) genotypes from Northeast Anatolia region of Turkey’, Scientia Horticulturae, 116(1), pp. 41–46. doi: 10.1016/j.scienta.2007.10.021.

De Freitas, M. M. et al. (2016) ‘Extracts of Morus nigra L Leaves Standardized in chlorogenic acid, rutin and isoquercitrin: Tyrosinase inhibition and cytotoxicity’, PLoS ONE, 11(9). doi: 10.1371/journal.pone.0163130.

Gundogdu, M. et al. (2011) ‘Determination of fruit chemical properties of Morus nigra L., Morus alba L. and Morus rubra L. by HPLC’, Scientia Horticulturae, 132(1), pp. 37–41. doi: 10.1016/j.scienta.2011.09.035.

Hojjatpanah, G., Fazaeli, M. & Emam-Djomeh, Z. (2011) ‘Effects of heating method and conditions on the quality attributes of black mulberry (Morus nigra) juice concentrate’, Int. J. Food Sci. Technol, 46, pp. 956–962.

Iqbal, S. et al. (2012) ‘Proximate composition and antioxidant potential of leaves from three varieties of mulberry (Morus sp.): A comparative study’, International Journal of Molecular Sciences, 13(6), pp. 6651–6664. doi: 10.3390/ijms13066651.

Khalid, N., Fawad, S. A. and Ahmed, I. (2011) ‘Antimicrobial Activity, Phytochemical Profile and Trace Minerals of Black Mulberry (Morus Nigra L.) Fresh Juice’, Pak. J. Bot, 43(December), pp. 91–96.

Koyuncu, F., Çetinbaş, M. and Ibrahim, E. (2014) ‘Nutritional Constituents of Wild-Grown Black Mulberry ( Morus nigra L .)’, Journal of Applied Botany and Food Quality, 87, pp. 93–96. doi: 10.5073/JABFQ.2014.087.014.

Kutlu, T. et al. (2011) ‘Farkli{dotless} karadut (morus nigra L.) ekstraktlari{dotless}ni{dotless}n antioksidan özellikleri’, Turkish Journal of Biology, 35(1), pp. 103–110. doi: 10.3906/biy-0904-22.

Liu, L. et al (2009) ‘Effects of mulberry (Morus alba L.) extracts on lipid homeostasis in vitro and in vivo’, Journal of Agricultural and Food Chemistry, 57, pp. 7605–7611.

Mazimba, O. (2011) ‘Antioxidant and antibacterial constituents from Morus nigra’, African Journal of Pharmacy and Pharmacology, 5(6), pp. 751–754. doi: 10.5897/AJPP11.260.

Memon, A. A. et al. (2010) ‘Phenolic Acids Profiling and Antioxidant Potential of Mulberry ( Morus Laevigata W ., Morus Nigra L ., Morus Alba L .) Leaves and Fruits Grown’, 60(1), pp. 25–32.

de Mesquita Padilha, M. et al. (2009) ‘Antinociceptive Effect of the Extract of Morus nigra Leaves in Mice’, Journal of Medicinal Food, 12(6), pp. 1381–1385. doi: 10.1089/jmf.2009.0012.

Miljković, Vojkan M. (Faculty of Technology, L. (Serbia)) et al. (2014) ‘Morus species through centuries in pharmacy and as food’, Savremene tehnologije / Advanced Technologies, 3(2), pp. 111–115. doi: 10.5937/savteh1402111m.

Özgen, M., Serçe, S. and Kaya, C. (2009) ‘Phytochemical and antioxidant properties of anthocyanin-rich Morus nigra and Morus rubra fruits’, Scientia Horticulturae, 119(3), pp. 275–279. doi: 10.1016/j.scienta.2008.08.007.

Padilha, M. M. et al. (2010) ‘Antiinflammatory properties of Morus nigra leaves’, Phytotherapy Research, 24(10), pp. 1496–1500. doi: 10.1002/ptr.3134.

de Queiroz, G. T. et al. (2012) ‘Efficacy of Morus nigra L. on reproduction in female Wistar rats’, Food and Chemical Toxicology. Elsevier Ltd, 50(3–4), pp. 816–822. doi: 10.1016/j.fct.2011.12.014.

R, V. K. and Chauhan, S. (2008) ‘Mulberry : Life enhancer’, J. Med. Plants Res., 2(10), pp. 271–278.

Radojkovic, M. et al. (2012) ‘Free radical scavenging activity, total phenolic and flavonoid contents of mulberry (Morus spp. L., Moraceae) extracts’, Hemijska industrija, 66(4), pp. 547–552. doi: 10.2298/HEMIND111111002R.

Sánchez-Salcedo, E. M. et al. (2015) ‘(Poly)phenolic compounds and antioxidant activity of white (Morus alba) and black (Morus nigra) mulberry leaves: Their potential for new products rich in phytochemicals’, Journal of Functional Foods. Elsevier Ltd, 18, pp. 1039–1046. doi: 10.1016/j.jff.2015.03.053.

Tchabo, W. et al. (2015) ‘Ultrasound-assisted enzymatic extraction (UAEE) of phytochemical compounds from mulberry (Morus nigra) must and optimization study using response surface methodology’, Industrial Crops and Products. Elsevier B.V., 63, pp. 214–225. doi: 10.1016/j.indcrop.2014.09.053.

Thabti, I. et al. (2014) ‘Phenols, flavonoids, and antioxidant and antibacterial activity of leaves and stem bark of morus species’, International Journal of Food Properties, 17(4), pp. 842–854. doi: 10.1080/10942912.2012.660722.

Ullah, M. et al. (2013) ‘An ethnobotanical survey of indigenous medicinal plants in Wana district south Waziristan agency, Pakistan’, Journal of Ethnopharmacology. Elsevier, 150(3), pp. 918–924. doi: 10.1016/j.jep.2013.09.032.

Wadood, A. (2013) ‘Phytochemical Analysis of Medicinal Plants Occurring in Local Area of Mardan’, Biochemistry & Analytical Biochemistry, 2(4). doi: 10.4172/2161-1009.1000144.

Yigit, D. and Yigit, N. (2009) ‘Antibacterial activity of black mulberry (Morus nigra) fruits and leaves’, Erzincan University Journal of Science and Technology.

Zheng, Z. P. et al. (2010) ‘Tyrosinase inhibitory constituents from the roots of Morus nigra: A structure-activity relationship study’, Journal of Agricultural and Food Chemistry, 58(9), pp. 5368–5373. doi: 10.1021/jf1003607.




DOI: https://doi.org/10.24198/jf.v16i2.17530

DOI (PDF (Bahasa Indonesia)): https://doi.org/10.24198/jf.v16i2.17530.g8759

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