ANDRIATI KHOERUNNISA, Insan Sunan Kurniawansyah


Antioxidants are compounds that can be synthetic or natural products. These compounds have a mechanism which suppresses or delays the oxidation process of other molecules because of free radicals. Free radicals such as reactive oxygen species (ROS) are produced during cellular metabolism and environmental such as heavy metal ions, cigarette smoke. Natural antioxidants have been developed from several parts of the plants which contain flavonoids, phenolic acids, tannins, quinones and other phenolic compounds. One of the many plants examined for its antioxidant activity is black mulberry (Morus nigra L.). Black mulberry is known for their high content of phenolic compound. Thus have high antioxidant activity. This review attempt to focus on the relationship between antioxidant activity of black mulberry and composition of phytochemicals, especially phenolic compounds in black mulberry and to explore other potential functions of black mulberry in medicinal uses.

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Ali, A, M Ali, S Mir, and B Ali. 2011. Phytochemical and biological screening of Morus alba (L.) Bark. Planta Medica 77: 14.

Ames, BN, MK Shigenaga, LS Gold. 1993. DNA lesions, inducible DNA repair, and cell division: three key factors in mutagenesis and carcinogenesis. Environ Health Perspect. 101: 35–44.

Arabshahi-Delouee, S, A Urooj. 2007. Antioxidant properties of various solvent of mulberry (Morus indica L.) leaves. Food Chem. 102: 1233–1240.

Arfan, M, R Khan, A Rybarczyk, R Amarowicz. 2012. Antioxidant Activity of Mulberry Fruit Extracts. Int. J. Mol. Sci. 13: 2472-2480.

Bae, SH, HJ Suh. 2007. Antioxidant activity of five different mulberry cultivars in Korea. LWT Food Sci. Technol. 40: 955–962.

Birben, E, UM Sahiner, C Sackesen, S Erzurum, O Kalayci. Oxidative Stress and Antioxidant Defense. WAO Jurnal 5: 9-19.

Brand-Williams, W, ME Cuvelier, and C Berset. 1995. Use of a free radical method to evaluate antioxidant activity. Lebensm.-Wiss. u.-Technol. 28: 25-30.

Cai, Y, Q Luo, M Sun, and H Corke. 2004. Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer. Life Sciences 74: 2157-2184.

Choi, CW, SC Kim, SS Hwang, BK Choi, HJ Ahn, MY Lee, SK Kim. 2002. Antioxidant activity and free radical scavenging capacity between Korean medicinal plants and flavonoids by assay-guided comparison. Plant Science 163: 1161–1168.

Chu, Q, M Lin, X Tian, J Ye. 2006. Study on capillary electrophoresis-amperometric detection profiles of different parts of Morus alba L. J. Chromatogr. A 1116: 286–290.

Datwyler, SL, and GD Weiblen. 2004. On the origin of the fig: Phylogenetic relationships of Moraceae from ndhF sequences. American Journal of Botany 91, 767–777.

Dhalla NS, RM Temsah, T Netticadan. 2000. Role of oxidative stress in cardiovascular diseases. J Hypertens. 18: 655–673.

DeFeudis, FV, V Papandopoulos and K Drieu. 2003. Ginkgo biloba extracts and cancer: a research area in its infancy. Fundam Clin Pharmacol. 17: 405–17.

Ercisli, S. 2004. A short review of the fruit germplasm resources of Turkey. Gen. Res. Crops Evol. 51: 419–435.

Ercisli, S, O Emine. 2007. Chemical composition of white (Morus alba), red (Morus rubra) and black (Morus nigra) mulberry fruits. Food Chem. 103, 1380–1384.

Ercisli, S, E Orhan. 2008. Some physico-chemical characteristics of black mulberry (Morus nigra L.) genotypes from Northeast Anatolia region of Turkey. Sci. Hortic. 116: 41–46.

Everett, TH. 1960. New illustrated encyclopedia of gardening. Greystone Press, New York.

Facciola, S. 1990. Cornucopia: a source book of edible plants. Kampong publications, Vista, California.

Geier, DA, et al. 2009. Biomarkers of environmental toxicity and susceptibility in autism. J Neurol Sci. 280: 101–8.

Gerasopoulos, D, G Stavroulakis. 1997. Quality characteristics of four mulberry (Morus species) cultivars in the area of Chania, Greece. J. Sci. Food Agric. 73: 261–264.

Giles, GI, C Jacob. 2002. Reactive sulfur species: an emerging concept in oxidative stress. Biol. Chem. 383: 375–88.

Guo, C, J Yang, J Wei, Y Li, J Xu, Y Jiang. 2003. Antioxidant activities of peel, pulp and seed fractions of common fruits as determined by FRAP assay. Nutr. Res. 23: 1719–1726.

Halliwell, B. 1994. Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? Lancet 344 (8924): 721–724.

Harauma, A.; T Murayama, K Ikeyama, H Sano, K Arai, R Takano, T Kita, S Hara, K Kamei, and M Yokode. 2007. Mulbery leaf powder prevent atherosclerosis in apolipoprotein E-deficient mice. Biochem. Biophys. Res. Commun. 358: 751–756.

Imran, M, H Khan, M Shah, R Khan, F Khan. 2011. Chemical composition and antioxidant activity of certain Morus species. J. Zheijang Univ.-Sci. B 11: 973–980.

Iqbal, S, MN Asghar, IL Khan, I Zia. 2010. Antioxidant potential profile of extracts from different parts of black mulberry. Asian J. Chem. 22: 353–363.

Jenner, P. 2003. Oxidative stress in Parkinson’s disease. Ann Neurol.53: 26–36.

Katsube, T, N Imawaka, Y Kawano, Y Yamazaki, K Shiwaku, and Y Yamane. 2006. Antioxidant flavonol glycosides in mulberry (Morus alba L.) leaves isolated based on LDL antioxidant activity. Food Chem. 97: 25–31.

Kerr, S, MJ Brosnan, M McIntyre, JL Reid, AF Dominiczak, CA Hamilton. 1999.Superoxide anion production is increased in a model of genetic hypertension: role of the endothelium. Hypertension. 33: 1353–1358.

Koca, I, NS Ustun, AF Koca, B Karadeniz. 2008. Chemical composition, antioxidant activity and anthocyanin profiles of purple mulberry (Morus rubra) fruits. J. Food Agric. Environ. 6: 39–42.

Kohen, R, A Nyska. 2002. Oxidation of biological systems: oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantifi cation. Toxicol Pathol 30: 620–630.

Kostić, DA, DS Dimitrijević, SS Mitić, MN Mintić, GS Stojanović, and AV Živanović. 2013. A survey on macro- and micro-elements, phenolic compounds, biological activity and use of Morus spp. (Moraceae). Fruits 68: 333-347.

Kunwar, A, KI Priyadarsini. 2011. Free radicals, oxidative stress and importance of antioxidants in human health. J Med Allied Sci 1: 53–60.

Kutlu, T, G Durmaz, B Ates, I Yilmaz, and MS Cetin. 2011. Antioxidant properties of different extracts of black mulberry (Morus nigra L.). Turk. J. Biol. 35: 103–110.

Lian, AP, H Hua, PH Chuong. 2008. Free radicals, antioxidants in disease and health. Int J Biol Sci 4: 89–96

Lü, JM, PH Lin, Q Yao, and C Chen. 2010. Chemical and molecular mechanism of antioxidants: experimental approaches and model system. J. Cell. Mol. Med 14 (4): 840-860.

Lyras, L, NJ Cairns, A Jenner, P Jenner, B Halliwell. 1997. An assessment of oxidative damage to proteins, lipids, and DNA in brain from patients with Alzheimer’s disease. J Neurochem. 68: 2061–2069.

Memon, AA, N Memon, LD Luthria, IM Bhanger, AA Pitafi. 2010. Phenolic acids profiling and antioxidant potential of mulberry (Morus leavigata W., Morus nigra L., Morus alba L.). Pol. J. Food Nutr. Sci. 60: 25–32.

Niki, E. 1997. Free radicals, antioxidants, and cancer, Pp. 55–57 in Food Factors for Cancer Prevention (H Ohigashi, T Osawa, J Terao, S Watanabe, T Yoshikawa, eds.). Springer, Tokyo.

Noori, S. 2012. An Overview of Oxidative Stress and Antioxidant Defensive System. Journal of Clinical & Cellular Immunology 1: 413.

Orban, E, S Ercisli. 2010. Genetic relationships between selected Turkish mulberry genotypes (Morus spp) based on RAPD markers. Gen. Mol. Res. 9: 2176-2183.

Ozgen, M, S Serce, K Kaya. 2009. Phytochemical and antioxidant properties of anthocyanin-rich Morus nigra L. and Morus rubra L. fruits. Sci. Hortic. 119: 275–279.

Park, KM, JS You, HY Lee, NI Baek, and JK Hwang. 2003. Kuwanon G: An antibacterial agent from the root bark of Morus alba against oral pathogens. Journal of Ethnopharmacology 84: 181–185.

Poulson, HE, H Prieme, S Loft. 1998. Role of oxidative DNA damage in cancer initiation and promotion. European Journal of Cancer Prevention 7 (1): 9–16.

Qin, J, M Fan, J He, XD Wu, LY Peng, J Su, QS Zhao. 2015. New cytotoxic and anti-inflammatory compounds isolated from Morus alba L. Natural Product Research 29: 1711–1718.

Radimer, K, et al. 2004. Dietary supplement use by US adults: data from the national health and nutrition examination survey, 1999–2000. Am J Epidemiol 160: 339–349

Rollinger, JM, A Bodensieck, C Seger, EP Ellmerer, R Bauer, T Langer, and H Stuppner. 2005. Discovering COX-Inhibiting constituents of Morus root bark: activity-guided versus computer-aided methods. Planta Medica 71: 399–405.

Rollinger, JM, et al. 2006. Venturia inaequalis Inhibiting Diels−Alder adducts from Morus root bark. Journal of Agricultural and Food Chemistry 54: 8432–8436.

Sayre, LM, MA Smith, G Perry. 2001. Chemistry and biochemistry of oxidative stress in neurodegenerative disease. Curr Med Chem. 8:721–738.

Sevanian, A, F Ursini. 2000. Lipid peroxidation in membranes and low-density lipoproteins: similarities and differences. Free Radic Biol Med 29: 306–311.

Srivastava, A, P Greenspan, DK Hartle, L James, JL Hargrove, R Amarowicz, RB Pegg. 2010. Antioxidant and anti-inflammatory activities of polyphenolics from southeastern U.S. range blackberry cultivars. J. Agric. Food Chem. 58: 6102–6109.

Tsai, PJ, L Delva, TY Yu, YT Huang, L Dufossé. 2005. Effect of sucrose on the anthocyanin and antioxidant capacity of mulberry extract during high temperature heating. Food Chem. 38: 1059–1065.

Velioglu, YS, G Mazza, L Gao, and BD Oomah. 1998. antioxidant activity and total phenolics in selected fruits, vegetables, and grain products. J. Agric. Food Chem. 46: 4113-4117.

Vertuani, S, A Angusti, S Manfredini. 2004. The antioxidants and pro-antioxidants network: an overview. Curr Pharm Des 10: 1677-1694.

Zelová, H, et al. 2014. Evaluation of anti-inflammatory activity of Prenylated substances isolated from Morus alba and Morus nigra. Journal of Natural Products 77: 1297–1303.

Zeng, Q, H Chen, C Zhang, M Han, T Li, X Qi, Z Xiang, and N He. 2015. Definition of eight mulberry species in the genus Morus by internal transcribed spacer-based phylogeny. PLoS ONE 10 (8).

Zhishen, J, T Mengcheng, W Jianming. 1999. The determination of flavonoid contents in mulberry and their scavenging effect on superoxide radicals. Food Chem. 64: 555–559.

Zhivotovsky, B, S Orrenius. 2011. Calcium and cell death mechanisms: a perspective from the cell death community. Cell Calcium 50: 211–221

DOI: https://doi.org/10.24198/jf.v16i2.17557

DOI (PDF): https://doi.org/10.24198/jf.v16i2.17557.g8771

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