ARTIKEL ULASAN: AKTIVITAS ANTIKANKER SPONS LAUT KELAS DEMOSPONGIAE

FITRAH SYAFIRA PUTRI, Yuni Elsa Hadisaputri

Abstract


Kanker adalah salah satu penyebab utama kematian di Dunia, yang menewaskan sekitar 8,8 juta orang dan jumlah ini terus meningkat hampir 80 juta per tahun. Pengobatan kanker konvensional dapat dilakukan dengan berbagai cara. Di Amerika dan Eropa diperkirakan 65% obat kanker berasal dari bahan alami secara komersial. Senyawa derivatif dari produk alami bioaktif memiliki target spesifik dan tidak memiliki efek samping. Sponge pada kelas demospongiae diketahui banyak memiliki aktivitas antikanker. Aktivitas ini berdasarkan nilai sitotoksiksitas (IC­50) terhadap sel kanker. Hasil dari penelusuran  menunjukkan bahwa beberapa sponge dari kelas demospongiae memiliki senyawa antikanker terhadap sel kanker payudara (T47D dan MCF-7), sel kanker serviks (HeLa dan Hep 2), kanker kolon (HCT116, HCT116p53KO, LoVo, caco-2), dan sel kanker prostat (PC-3). Sehingga dapat disimpulkan bahwa beberapa spons kelas demospongiae memiliki sifat sitotoksik terhadap 9 sel lini kanker


References


DAFTAR PUSTAKA

Amir, S. et al.2013. Phylogeny of Tetillidae (Porifera, Demospongiae, Spirophorida) Based on Three Molecular Markers. Molecular Phylogenetics and Evolution, 67(2), p. 509–519.

Arafeh, K. & Ullah, N.2009. Synthesis of neolamellarin A, an inhibitor of hypoxia-inducible factor-1. Nat. Prod. Commun., Volume 4, p. 925–926..

B, V. B., Vinod, V. & M Cindhu, B.2011. Biopotential of secondary metabolites isolated from marine sponge. Asian Pacific Journal of Tropical Disease , 1(4), pp. 299-303.

Christian, B.2015. Review: Anticancer Properties of Lamellarins. Mar. Drugs, 13(3), pp. 1105-1123.

Delphine, L.-T.et al.2011. Evaluation of the Antiproliferative Activity of Diterpene Isonitriles from the Sponge Pseudoaxinella flava in Apoptosis-Sensitive and Apoptosis-Resistant Cancer Cell Lines. J. Nat. Prod., 74(10), p. 2299–2303.

Devita, V. T. & Chu, E.2008. A history of Cancer Chemotherapy. Cancer Res, 68(21), pp. 8643-8653.

Hochmuth, T., et al.2010. Linking Chemical and Microbial Diversity in Marine Sponges; Possible Role for Poribakteria as Producers of Methyl-Branched Fatty Acids. ChemBioChem, 11,(18), pp. 2572-2578.

I Made Dira, S., Wiwik, S. R. & dan Rr. Anisa, H.2017. ISOLATION AND PHYTOCHEMICAL TEST OF ANTICANCER ISOLATE OF SPONGE Hyrtios erecta. IRSC UNUD Journals, 1(1), pp. 16-19.

KA, E.-D.et al.2017. Biological activities of some marine sponge extracts from Aqaba Gulf, Red Sea, Egypt. International Journal of Fisheries and Aquatic Studies , 5(2), pp. 652-659.

Kiheon, C. et al.2017. Anticancer Effects of the Marine Sponge Lipastrotethya sp. Extract on Wild-Type and p53 Knockout HCT116 Cells. Evid Based Complement Alternat Med, Volume 2017, pp. 1-6.

Lakshmi, V. et al.2010. Antifungal activity of marine sponge Haliclona exigua ( Krikpatric). Journal de Mycologie Médicale, Volume 20, pp. 31-35.

Lee, J.-H., Jang, K. H., Lee, Y.-J, et al.2011. Triterpene galactosides of the pouoside class and corresponding aglycones from the sponge Lipastrotethya sp. Journal of Natural Products, 74(12), p. 2563–2570.

Li, Y.-X., Himaya, S. W. A. & dan S.-K. Kim, et al.2013. Triterpenoids of marine origin as anti-cancer agents. Molecules,, 18(7), p. 7886–7909.

Momose, R., Tanaka, N., Fromont, J. & Kobayashi, d. J.2013. Hyrtimomines A-C, New Heteroaromatic Alkaloids from a Sponge Hyrtios sp.. ORGANIC LETTERS, 15(8), pp. 2010-2013.

Morrow, C. & Cárdenas, P.2015. Proposal for a revised classification of the Demospongiae (Porifera). Frontiers in Zoology, 12(7), pp. 1-27.

Nurhayati, A. P. D. et al.2014. The Anticancer Activity of Marine Sponge Cinachyrella sp. (Family Tetillidae). IPTEK, The Journal for Technology and Science, 25(3), pp. 71-77.

Observatory, G. H.2018. WHO. [Online]

Available at: http://www.who.int/cancer/en/

[Accessed 3 July 2018].

OK, R. et al. 2007. Antibacterial activity of marine bacteria associated with sponge Aaptos sp. against Multi drug resistant (MDR) strains. Jurnal Matematika dan sains, 12(4), pp. 147-152.

Pallela, R., Koigoora, S., Gunda, V. G. & Madhavendra.2011. Comparative morphometry, biochemical and elemental composition of three marine sponges. Chemical Speciation & Bioavailability, 23(1), pp. 16-23.

Qiu, Z., Hongyu, Z., Shumei, Z. & dan Bing, Y.2010. Natural Product-Inspired Synthesis of Thiazolidine and Thiazolidinone Compounds and their Anticancer Activity. Current Pharmaceutical Design, 16(16), pp. 1826-1842 .

Shimogawa, H. et al.2006. Cinachyramine, The Noval Alkalid Possessing a Hydrazone and Two Aminals from Cinachyrella sp. Tetrahedron Letters,, 47(9), pp. 1409-1411.

Ullah, M. F. & Aatif, M.2009. The Footprints of Cancer Development : Cancer Biomarker. Cancer Treatment Reviews, 35(3), pp. 193-200.

VALENTIN, B. B., BEULAH, M. C. & VINOD, d. V.2013. EFFICACY OF BIOACTIVE COMPOUNDS EXTRACTED FROM MARINE SPONGE HALICLONA. Asian Journal of Pharmaceutical and Clinical Research, 6(2), pp. 347-349.

Wen, F. H. et al.2014. Hainanerectamines A–C, Alkaloids from the Hainan Sponge Hyrtios erecta. Mar. Drugs, Volume 12, pp. 3982-2993.




DOI: https://doi.org/10.24198/jf.v16i2.17563

DOI (PDF (Bahasa Indonesia)): https://doi.org/10.24198/jf.v16i2.17563.g8774

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