POLIMORFISME GEN SLC11AI, ABCB1, DAN VDR SERTA ASOSIASINYA DENGAN TUBERKULOSIS MULTIDRUG-RESISTANT

MAURA SYAFA ISLAMI

Abstract


Tuberkulosis (TB) adalah suatu penyakit menular yang disebabkan oleh bakteri Mycobacterium tuberculosis. Penyakit ini kemudian berkembang menjadi semakin berbahaya dengan ditemukannya kasus tuberkulosis multidrug-resistant (TB-MDR) yang merupakan suatu keadaan di mana terjadi resistensi terhadap sekurang-kurangnya dua jenis obat antituberkulosis (OAT) poten yaitu isoniazid dan rifampisin. Dengan berkembangnya ilmu pengetahuan dan penelitian-penelitian terhadap TB-MDR, diketahui bahwa tidak hanya M.tuberculosis, tetapi adanya mutasi pada satu basa atau single nucleotide polymorphism (SNP) pada gen manusia yang merupakan inang, turut berperan dalam peningkatan resiko terjadinya TB-MDR. Beberapa gen yang dicurigai menjadi faktor resiko TB-MDR yang akan dibahas pada studi pustaka ini diantaranya adalah solute carrier family 11 member 1 (SLC11A1), ATP-binding cassette B1 (ABCB1), serta vitamin D reseptor (VDR).


References


Aranow, C., 2011. Vitamin D and the Immune System. J Investig Med, 59(6), pp. 881-886.

Bikle, D., 2009. Nonclassic Actions of Vitamin D. J Clin Endocrinol Metab, 94(1), pp. 26-34.

Challenge TB, 2017. Generic Programmatic and Clinical Guide for the Introduction of New Drugs and Shorter Regimens for the Treatment of Multi/Extensively Drug-Resistant Tuberculosis. USA: KNCV Tuberculosis Foundation.

Cherayil, B. J., 2011. The role of iron in the immune response to bacterial infection. Immunol Res., 50(1), pp. 1-9.

Coussens, A. K., Martineau, A. R. & Wilkinson, R. J., 2014. Anti-Inflammatory and Antimicrobial Actions of Vitamin D in Combating TB/HIV. Scientifica, Volume ID 903680, pp. 1-13.

Gandhi, N. R. et al., 2010. Multidrug-resistant and extensively drug-resistant tuberculosis: a threat to global control of tuberculosis. The Lancet, Volume 375, pp. 1830-1843.

Gao, L., Tao, Y., Zhang, L. & Jin, Q., 2010. Vitamin D receptor genetic polymorphisms and tuberculosis:. Int J Tuber Lung Dis, 14(1), pp. 15-23.

Hartkoorn, R. C. et al., 2007. Differential Drug Susceptibility of Intracellular and Extracellular Tuberculosis, and the Impact of P-glycoprotein. Tuberculosis, 87(3), pp. 248-255.

Hedges, J. F. et al., 2013. SLC11A1 is expressed by innate lymphocytes and augments their activation1. J. Immunol, April, 190(8), pp. 4263-4273.

Holick, M. F., 2007. Vitamin D Deficiency. N Engl J Med, Volume 357, pp. 266-281.

Huang, S.-J.et al., 2017. Vitamin D deficiency and the risk of tuberculosis: a meta-analysis. Drug Design, Development and Therapy, Volume 11, pp. 91-102.

Huls, M., Russel, F. G. M. & Masereeuw, R., 2008. The Role of ATP Binding Cassette Transporters in Tissue. Journal of Pharmacology and Experimental Therapeutics, 328(1), pp. 3-9.

Jin, J. et al., 2009. SLC11A1 (Formerly NRAMP1) Gene Polymorphisms Associated with Pediatric Tuberculosis in China. Clinical Infectious Disease, 15 Maret, 48(6), pp. 733-738.

Kementrian Kesehatan RI, 2017. Petunjuk Teknis Pengobatan Pasien TB Resisten Obat dengan Paduan Standar Jangka Pendek di Fasyankes TB Resisten Obat. Jakarta: Dirjen Pencegahan dan Pengendalian Penyakit.

Li, X. et al., 2011. SLC11A1 (NRAMP1) Polymorphisms and Tuberculosis Susceptibility: Updated Systematic Review and Meta-Analysis. Plos One, 25 Januari, 6(1), p. e15831.

Magee, M. J. et al., 2017. Polymorphisms in the vitamin D receptor. Plos One, 12(7e0180916).

McCullough, M. L., Bostick, R. M. & Mayo, T. L., 2009. Vitamin D gene pathway polymorphisms and risk of colorectal, breast, and prostate cancer. Annu Rev Nutr, Volume 29, pp. 111-132.

Meilang, Q. et al., 2012. Polymorphisms in the SLC11A1 gene and tuberculosis risk: a meta-analysis update. Int J Tuberc Lung Dis, 16(4), pp. 437-446.

Mostowska, A. et al., 2013. Vitamin D receptor gene BsmI, FokI, ApaI and TaqI polymorphisms and the risk of systemic lupus erythematosus. Mol Biol Rep, 40(2), pp. 803-810.

Muangsombut, V. et al., 2017. Burkholderia pseudomallei Evades Nramp1 (Slc11a1)- and NADPH Oxidase-Mediated Killing in Macrophages and Exhibits Nramp1-Dependent Virulence Gene Expression. Front. Cell. Infect. Microbiol, Volume 7, p. 350.

Müller, B., Borrell, S., Rose, G. & Gagneux, S., 2013. The Heterogeneous Evolution of Multidrug-Resistant Mycobacterium tuberculosis. Trends Genet, Mar, 29(3), pp. 160-169.

O'Brien, B. A. et al., 2008. Association of SLC11A1 promoter polymorphisms with the incidence of autoimmune and inflammatory disease: A meta-analysis. Journal of Autoimmunity, 31(1), pp. 42-51.

Pontual, Y. et al., 2017. ABCB1 gene polymorphism associated with clinical factors can predict drugresistant. Clinical Science, 131(15), pp. 1831-1840.

Prietl, B., Treiber, G., Pieber, T. R. & Amrein, K., 2013. Vitamin D and Immune Function. Nutrients, Volume 5, pp. 2502-2521.

Rathored, J. et al., 2012. Risk and outcome of multidrug-resistant tuberculosis:. Int J Tuber Lung Dis, 16(11), pp. 1522-1528.

Rodríguez-Castillo, J. A. et al., 2015. Possible Association of Rare Polymorphysm in the ABCB1 gene with Rifampin and Ethambutol Drug-Resistant Tuberculosis. Tuberculosis, 1(6), pp. 1-6.

Sharom, F. J., 2011. The P glycoprotein multidrug. Essays Biochem, 50(1), pp. 161-178.

Takahashi, K. et al., 2008. SLC11A1 (formerly NRAMP1) polymorphisms associated with multidrug-resistant tuberculosis. Tuberculosis, 88(1), pp. 52-57.

Tovilla-Zárate, C. A. et al., 2014. Association study between the MDR1 gene and clinical characteristics in schizophrenia. Rev Bras Psiquiatr, 36(3), pp. 227-232.

Velez, D. R. et al., 2009. Association of SLC11A1 with tuberculosis interactions with NOS2A and TLR2 in African-Americans and Caucasians. Int J Tuber Lung Dis, 13(9), pp. 1068-1076.

Weiss, G. & Schaible, U. E., 2015. Macrophage defense mechanisms against intracellular bacteria. Immunol Rev., 264(1), pp. 182-203.

World Health Organization , 2010. The Global Plan to Sop TB 2011-2015: Transforming the Fight Towards Elimination of Tuberculosis. Geneva: World Health Organization.




DOI: https://doi.org/10.24198/jf.v16i2.17608

DOI (PDF (Bahasa Indonesia)): https://doi.org/10.24198/jf.v16i2.17608.g8792

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