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Review: Formulasi dan Evaluasi Sediaan Oral Effervescent
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Rute pemberian oral menjadi rute pemberian yang paling popular dan paling sering digunakan dalam pengobatan pasien. Namun, salah satu masalah yang sering ditemui pada pasien dalam melakukan terapi dengan rute pemberian oral adalah adanya tidak kepatuhan dalam mengkonsumsi obat. Rasa yang tidak enak serta kemampuan beberapa pasien terutama lansia dan anak kecil yang tidak dapat menelan tablet menjadi alasannya. Effervescent menjadi salah satu alternatif yang dapat digunakan dalam mengatasi masalah tersebut. Review ini akan menggambarkan beberapa formulasi dan evaluasi sediaan effervescent serta penerapannya dalam beberapa sistem pemberian obat terbaru. Pencarian literatur dilakukan menggunakan bantuan situs pencarian jurnal online Pubmed, dan ditemukan 21 artikel dari 265 artikel yang sesuai dengan kriteria inklusi. Dari 21 artikel ini, 16 diantaranya adalah formulasi tablet effervescent. Metode granulasi basah diketahui merupakan metode terbaik dalam formulasi effervescent karena dapat meningkatkan daya alir serta indeks kompresibilitasnya. Asam sitrat dan natrium karbonat menjadi kombinasi agen effervescent yang paling sering digunakan.
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