I. Maesaroh et al / Indo J Pharm 1 (2020) 14-19
18
the formula that meets the requirements of good
ointment adhesion is F1 and F3 with values of more
than 4 seconds [10].
Homogeneity and normality tests show the
results that the data are homogeneous and normal
with a signicance value> 0.05, so that it can be
followed by one-way ANOVA analysis. After one
way ANOVA analysis was carried out it showed
signicance results> 0.05. Signicance> 0.05
states that there is no eect of variations in the base
of the ointment on the physical characteristics of
the ointment of sapodilla manila leaf extract, so
that from these results it is concluded that there
is no signicant dierence from the test results of
the ointment test of sapodilla manila leaf extract
between the ointment base in formula one with in
other ointment formulas.
F. Viscosity
The viscosity test of ointment preparations aims
to see the thickness of the ointment preparations
that have been made. The value of viscosity range
by SNI 16-4399-1996 is in the range of viscosity
values 2000 - 50,000 cPas.
Table 8. Test Results of Ointment Viscosity of Manilkara
zapota L Leaf Extract Using Ointment Base
Variations
Formula cPas (Average ± SD)
F1 7880 ± 738,39
F2 3,00 ± 1,00
F3 6,00 ± 3,00
F4 10064,6 ± 138,07
Of the 4 formulas there are only 3 formulas that
meet the requirements, namely F1, F2, F4. Formula
F3 with a base can be washed with water, Test
result of ointment viscosity on formula F3 because
formula F3 has a very high level of viscosity, this
is due to the consistent base of the ointment that is
used is very thick than other ointment bases and also
occurs because the stickiness test on the F3 ointment
has a stickiness with more time long is 6 seconds,
where the adhesion is aected on the viscosity of
the preparation. Viscosity has a relationship with
viscosity, the longer the viscosity of the ointment,
the higher the viscosity value produced [15].
Besides being inuenced by dierences in the
base of the ointment. The viscosity value in the
preparation is inuenced by temperature, the higher
the temperature, the smaller the viscosity value.
Viscosity is also aected by storage time [16].
The results of the viscosity of the ointment from
sapodilla manila leaf extract with variations in this
base can only be analyzed descriptively.
4. Conclusion
Manilkara zapota L leaf extract can be formulated
as an ointment preparation. Variation of ointment
base on the ointment preparation formulation of
Manilkara zapota L leaf extract aects the results
of the ointment physical characteristics test where
the results of each ointment characteristic test have
a signicant dierence including the spreadability.
However, to test the physical characteristics of pH,
homogeneity, organoleptic, adhesion, and viscosity
have dierences but are not signicant.
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