Senyawa Kalkon dan turunannya serta Potensinya sebagai Antikanker : Literatur Review
Abstract
Salah satu senyawa yang memiliki potensi sebagai antikanker adalah Kalkon. Senyawa kalkon (1,3-difenil-2-propena-1-on) memiliki satu atom karbon a,ß-tak jenuh. Pada cincin A terdapat gugus metil, etil atau alkil sedangkan pada cincin B terdapat gugus halogen, siano dan nitro yang juga dapat meningkatkan aktivitas farmakologi. Dalam telaah pustaka ini, kami mengumpulkan informasi dari 25 penelitian terbaru selama 10 tahun terakhir untuk mendapatkan pemahaman yang mendalam tentang potensi senyawa kalkon. Kami mengidentifikasi bahwa penelitian in silico dan in vitro telah memberikan wawasan penting tentang interaksi kalkon dengan reseptor kanker dan aktivitasnya terhadap berbagai jenis sel kanker. Temuan ini dapat memberikan kontribusi signifikan pada pengembangan terapi antikanker yang efektif. Pencarian pustaka melalui basis data elektronik Google Scholar dan PubMed pada bulan Juni 2022 – Desember 2023 dengan kata kunci “Senyawa Kalkon”, “Potensi”,“Antikanker”, “Chalcone and Its Potential as Anticancer” dan “Kalkon dan Potensinya sebagai Antikanker” memperoleh total 25 penelitian, yaitu sebanyak 7 penelitian tentang in silico dan 18 penelitian in vitro. Hasil penelitian menunjukkan bahwa senyawa kalkon dan turunannya memiliki potensi sebagai agen antikanker. Penelitian in silico mengungkapkan interaksi yang kuat antara kalkon dan reseptor kanker, sementara penelitian in vitro mengkonfirmasi aktivitas antikanker pada berbagai jenis sel, termasuk sel kanker payudara, prostat, dan leukemia. Hasil uji aktivitas antikanker juga mencakup senyawa dengan turunan kalkon seperti metoksi hidroksi kalkon dan naftalen kalkon. Studi ini memberikan kontribusi signifikan dalam pemahaman potensi senyawa kalkon sebagai kandidat obat antikanker dan mendorong pengembangan lebih lanjut dalam bidang ini.
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DOI: https://doi.org/10.15416/ijcp.2022.11.4.360
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