Pembuatan dan Karakterisasi Self Emulsifying Drug Delivery Systems(SEDDS) Ibuprofen Secara Oral
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Self emulsifying drug delivery systems (SEDDS) dikembangkan sebagai metode untuk meningkatkan kelarutan obat lipofilik seperti ibuprofen, serta untuk meningkatkan absorpsi dan laju disolusi obat. Oleh karena itu penelitian ini bertujuan untuk mengembangkan formulasi SEDDS ibuprofen yang memenuhi syarat secara farmasetik dan meningkatkan bioavailabilitas ibuprofen. Formula SEDDS diperoleh dari uji kelarutan ibuprofen dan optimasi formula pada berbagai konsentrasi minyak, surfaktan dan kosurfaktan. Asam oleat, cremophor RH 40 dan propilenglikol masing-masing terpilih sebagai minyak, surfaktan dan kosurfaktan dengan perbandingan fase minyak : (surfaktan + kosurfaktan) 1:9 dan pebandingan surfaktan : kosurfaktan (3:2). Formula SEDDS optimum dievaluasi meliputi pengukuran persen transmitan, pengujian dispersibilitas, pengujian robustness, pengujian stabilitas (sentrifugasi, heating cooling cycle, freeze thaw cycle), penentuan ukuran partikel dan uji laju disolusi. Formula SEDDS ibuprofen terbaik memenuhi persyaratan persen transmitan (99,7% ± 0,872), waktu dispersibilitas (41,48 detik ± 1,3), stabil pada pengujian robustness, tidak terjadi pemisahan fasa pada pengujian stabilitas, serta memiliki ukuran globul dalam kisaran mikrometer yaitu 114,7 ± 0,692 nm. Hasil uji laju disolusi in vitro pada menit ke-10 menunjukkan bahwa sediaan SEDDS ibuprofen lebih tinggi dibandingkan dengan serbuk ibuprofen murni, yaitu masing-masing sebesar 90,04 ± 1,764% dan 59,30 ± 1,638%.
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Kohli, K., Chopra, S., Dhar, D., Arora, S., Khar, R.K. Self-emulsifying drug delivery systems : an approach to enhance oral bioavailability. Drug Discovery Today. 2010;15(21/22):958-965.
Zanchetta, B., Chaud, M.V., Santana, M.H.A. Self-emulsifying drug delivery system (SEDDS) in pharmaceutical development. J Adv Chem Eng. 2015;5(3).
Saritha, D., Bose, P.S.C., Nagaraju, R. Formulation and Evaluation of Self-emulsifying drug delivery systems (SEDDS) of Ibuprofen. IJPSR. 2014;5(9):3511-3519.
Gutierrez, J.M., Gonzales, C., Maestro, A., Sole, I., Pey, C.M., Nolla, J. Nano-emulsions : New applications and optimization of their preparation. Current Opinion in Colloid & Interface Science 13. 2008;245-251.
Chavda, H., Patel, J., Chavada, G., Dave, S., Patel, A., Patel, C. Self-nanoemulsifying powder of isotretinoin: preparation and characterization. Journal of Powder Technology. 2013;1-9.
Shah, S.E., Parikh, R.H., Chavda, J.R., Sheth, N.R. Self-nanoemulsifying drug delivery system of glimepiride : Design, development and optimization. J Pharm Sci and Tech. 2013;67(3):201-213.
Wadhwa, J., Asthana, A., Shilakari, G., Chopra, A.K., Singh, R. Development and evaluation of nanoemulsifying preconcentrate of curcumin for colon delivery. The Scientific World Journal. 2015;1-15.
Senapati, P.C., Sahoo, S.K., Sahu, A.N. Mixed surfactant based (SNEDDS) self-nanoemulsifying drug delivery system presenting efavirenz for enhancement of oral bioavailability. Biomed Pharmacother. 2016;80:42-51.
Nasr A, Gardouh A, Ghonaim H, Abdelghany E, Ghorab M. Effect of oils, surfactants and cosurfactants on phase behavior and physicochemical properties of self-nanoemulsifying drug delivery system (SNEDDS) for irbesartan and olmesartan. Int j app pharm. 2016;8(1):13-24.
Zhao, Y., Wang C., Chow A.H.L., Ren K., Gong T., Zhang Z., Zhenga Y. Self-nanoemulsifying drug delivery system (SNEDDS) for oral delivery of Zedoary essential oil: Formulation and bioavailability studies. International Journal of Pharmaceutics. 2010;383: 170-177.
Anindhita, M.A., Oktaviani, N. Formulasi self-nanoemulsifying drug delivery system (SNEDDS) ekstrak daun pepaya (Carica papaya l.) dengan virgin coconut oil (VCO) sebagai minyak pembawa. Jurnal Pena Medika. 2016;6(2).
Amrutkar, C., Salunkhe, K., Chaudhari S. Study on self nano emulsifying drug delivery system of poorly water soluble drug rosuvastatin calcium. World Journal of Pharmaceutical Research. 2014;3(4):2137-2151.
Priani, S.E., Nurrayyan., Darusman, F. Formulasi self nano emulsifying drug delivery system (SNEDDS) glimepirid dengan fasa minyak asam oleat. Jurnal Pharmaciana. 2017;7(2); 267-276.
Sharma, S., Sharma, A.D., Naseer, M.D.A., Singh, R. Formulation and evaluation of self emulsifying drug delivery system of iburofen using castor oil. Int J Pharm Pharm Sci. 2011;3(4):299-302
Nicholas, O., Lydia, U., Lawrence, E., Sunday, O., Vegil, O., Amarauche, C. Ibuprofen self-emulsifying drug delivery system. World journal of pharmacy and pharmaceutical sciences. 2015;4(02):887-899.
Parthasarathi, K.P., Mudit, D., Prudhvi, R., Lavanya, D., Krishna, L.N.V. Formulation and evaluation of positively charged self-emulsifying drug delivery systems containing ibuprofen. International Research Journal of Pharmacy. 2011;2(8):82-91.
Indriani, V., Tobing, N.E.K.P., Rijai, L. Formulasi self-nanoemulsifying drug delivery system (SNEDDS) ekstrak biji ramania (bouea macrophylla griff) dengan asam oleat (oleic acid) sebagai minyak pembawa. Proceeding of Mulawarman Pharmaceuticals Conferences. 2018;8(1):276-284.
Tan, M.E., He, C.H., Jiang, W., et al. Development of solid lipid nanoparticles containing total flavonoid extract from Dracocephalum moldavica L. and their therapeutic effect against myocardial ischemia-reperfusion injury in rats. Int J Nanomedicine. 2017;12:3253-3265.
Gursoy RN, Benita S. Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs. Biomed Pharmacother. 2004;58(3):173-182.
Sharma, R., Katageri, S.B. Development, optimization and characterization of oral solid self nanoemulsifying drug delivery systems (S-SNEDDS) of repaglinide tablets for type-II diabetes. International Journal for Pharmaceutical Research Scholars. 2015;4(I-3);123-138.
DOI: https://doi.org/10.24198/ijpst.v9i2.31508
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