Antipyretic And Antiinflammatory Activities Of Bopot Leaf Extract From Kutai Kartanegara District

Chaerul Fadly Mochtar; Novia Misnawati Aisyiyah; Qur’anni Akhwatun Husna; Hasyrul Hamzah; Muh Irham Bakhtiar; Reni Selviana Devi; Fathiah Putri Varizza; Ayu Faradillah; Elva Hafidzah; Suriati Suriati; Nur Lutfiah Damis

doi:10.24198/ijpst.v0i0.46188

Antipyretic And Antiinflammatory Activities Of Bopot Leaf Extract From Kutai Kartanegara District

Chaerul Fadly Mochtar, Novia Misnawati Aisyiyah, Qur’anni Akhwatun Husna, Hasyrul Hamzah, Muh Irham Bakhtiar, Reni Selviana Devi, Fathiah Putri Varizza, Ayu Faradillah, Elva Hafidzah, Suriati Suriati, Nur Lutfiah Damis

Sari

Fever, a condition where the body temperature is above normal (> 37°C) can occur due to inflammation, an immune system response from harmful stimuli such as pathogens. Bopot leaves (Tabernaemontana divaricata) contain flavonoids, tannins, saponins and alkaloids which are thought to play a role in inhibiting prostaglandin synthesis (PGE2). This research was conducted to determine the antipyretic and anti-inflammatory activity of Bopot leaves. In vivo testing was used in mice (Mus musculus). The antipyretic test used peptone induction and rectal temperature was measured using a digital thermometer, while the anti-inflammatory test was carrageenin induced and the volume of edema was measured using a plethysmometer. Measurements were made before and after induction with an interval of 30 minutes for 2 hours. Results were analyzed by ANOVA using SPSS. The antipyretic test showed that the dose of 200 mg/Kg BW had the best antipyretic activity with an antipyretic power of 90.20% and the best anti-inflammatory activity at a dose of 250 mg/Kg BW. Bopot leaves contain flavanoid compounds which have antipyretic and anti-inflammatory effects by inhibiting cyclooxygenase (COX) which triggers prostaglandins that cause an increase in body temperature and inflammation. It was concluded that Bopot leaf extract has antipyretic and anti-inflammatory activity.

Kata Kunci

Antipyretic; anti-inflammatory; bopot leaves; peptone; carrageenan

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Referensi

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DOI: https://doi.org/10.24198/ijpst.v0i0.46188