Formulasi Masker Gel Peel-Off Kulit Buah Manggis (Garcinia mangostana Linn.)

Sani E Priani, Irma Irawati, Gita C. E. Darma

Abstrak


Kulit buah manggis (Garcinia mangostana Linn.) mengandung senyawa xanton yang diketahui memiliki aktivitas antioksidan yang tinggi. Penelitian sebelumnya menunjukkan bahwa Fraksi Etil Asetat Kulit Buah Manggis (FEAKBM) memiliki aktivitas antioksidan paling tinggi dibandingkan fraksi air dan n-heksan. Penelitian ini bertujuan untuk membuat formulasi dan mengarakterisasi sediaan masker gel peel-off mengandung FEAKBM. Masker gel peel-off diformulasi menggunakan Polivinil Alkohol (PVA) dan Hidroksi Propil Metil Selulosa (HPMC) sebagai gelling agent. Uji aktivitas antioksidan dari fraksi dan sediaan dilakukan secara in-vitro dengan uji peredaman DPPH. Terhadap sediaan dilakukan evaluasi pH, viskositas, daya sebar, dan waktu mengering. Fraksi etil asetat kulit buah manggis memiliki aktivitas antioksidan sangat tinggi dengan nilai IC50 19,240 µg/mL. Formula optimum basis masker gel mengandung PVA 14% dan HPMC 1%. Sediaan masker gel peel-off  stabil berdasarkan uji stabilitas fisik pada suhu 40 oC selama 28 hari penyimpanan. Sediaan masker gel peel-off mengandung FEAKBM 1% memiliki aktivitas antioksidan dengan nilai persen inhibisi 53,57±0,591.

 

Kata kunci: Fraksi etil asetat, kulit buah manggis, masker gel peel-off


Teks Lengkap:

PDF

Referensi


Chaverri JD, Noemí CR, Marisol OI, Jazmin M, Perez R. Medicinal properties of mangosteen (Garcinia mangostana). Food and Chemical Toxicology. 2008;46:3227–3239.

Jung H, Baoning S, William JK. Antioxidant xanthones from the pericarp of Garcinia mangostana (Mangosteen). J. Agric. Food Chem. 2006;54:2077–2082.

Zarena AS, Kadimi US. A study of antioxidant properties from Garcinia Mangostana L. pericarp extract. Acta Sci. Pol., Technol. Aliment. 2009;8(1): 23–34.

Chaovanalikit A, Mingmuang A, Kitbunluewit T, Choldumrongkool N, Sondee J, Chupratum S. Anthocyanin and total phenolics content of mangosteen and effect of processing on the quality of mangosteen products, International Food Research Journal. 2012;19(3):1047–1053.

Zhou HC, Yi-Ming L, Shu-Dong W, Nora FT. Structural diversity and antioxidant activity of condensed tannins fractionated from mangosteen pericarp. Food Chemistry. 2011;129 (4):1710–1720

Pandel R, Borut P, Aleksandar G, Raja D. Skin photoaging and the role of antioxidants in its prevention. ISRN Dermatology; 2013:1–11.

Dimitrios B. Sources of natural phenolic antioxidants. Trends in Food Science & Technology. 2006;17:505–512.

Arif NJ, Azli Y, Mariani AH, Harisun Y, Razauden MZ. Development of lightening cream from mangosteen pericarp extract with olive oil emulsifier. International Conference on Education, Research and Innovation. 2014;68(10):58–65.

Widyanati P, Mahdi J, Berna E, Iskandarsyah. Formulation and penetration study of liposome gel xanthone of extract mangosteen pericarp (Garcinia mangostana L.), Int. J. Pharm. Sci. Rev. Res. 2014; 27(2):1–6.

Shai A. Handbook of cosmetic skin care, edisi ke-II. USA: Informa Healt Care; 2009.

Vieira RP. Physical and physicochemical stability evaluation of cosmetic formulations containing soybean extract fermented by bifidobacterium animalis. Brazilian Journal of Pharmaceutical Sciences. 2009;45(3):515–525.

Berighs AO, Julia MR, Hellen KS, Rosane MB, Diva S. Green clay and aloe vera peel-off facial masks: response surface methodology applied to the formulation design. AAPS Pharm Sci Tech. 2013;14(1):445–455.

Priani SE, Yani L, Nabila. Formulasi mikroemulsi fraksi etil asetat kulit buah manggis. Jurnal Bahan Alam Indonesia. 2013;8(6).

Molyneux P. The use of the stable free radical diphenylpicrylhydrazyl (DPPH) for estimating antioxidant activity. J. Sci. Technol. 2004;26(2):211–219.

Setha B, Febe FG, Andi PS, Samsul R, Meigy NM. Potential of seaweed Padina sp. as a source of antioxidant, International of Scientific and Technology research. 2013;2(6):221– 224.

Zarena AS, Udaya S. Screening of xanthone from mangosteen (Garcinia mangostana L.) peels and their effect on cytochrome c reductase and phosphomolybdenum activity. Journal of Natural Products. 2009;2:23–30.

Birck C, Degoutin S, Tabary N, Miri V, Bacquet M. New crosslinked cast films based on poly (vinyl alcohol): preparation and physico-chemical properties. Express Polymer Letters. 2014;8(12):941–952.

Schmid-Wendtner MH, Korting HC. The pH of the skin surface and its impact on the barrier function. Skin Pharmacol Physiol. 2006;19:296–302.

Garg A, Deepeka A, Garg S, Singla AK. Spreading of semisolid formulation. Pharmaceutical Tecnology. 2002:9;84–104.

De Winter JCF. Using the student’s t-test with extremely small sample sizes. Practical Assessment, Research & Evaluation. 2013;18(10):1–12.




DOI: https://doi.org/10.15416/ijpst.v2i3.7905

Refbacks

  • Saat ini tidak ada refbacks.


Copyright © 2016 IJPST.

Switch to English

Universitas Padjadjaran. Back to Top

View My Stats