Anti-inflammatory properties of mangosteen peel extract on the mice gingival inflammation healing process

Khairani Putri, Lusiana Darsono, Henry Mandalas

Abstract


Introduction: Mangosteen (Garcinia Mangostana L.) peel extract has widely used in the pharmaceutical field due to its anticancer, anti-inflammatory, antibacterial, and immunity boost properties. It had been proofed to be able to prevent and reduce the amount of plaque and cure gingivitis. This study was aimed to compare mangosteen peel extract at the concentration of 12.5 and 25% on the mouse gingival inflam­mation healing process. Methods: This study was a true experimental laboratory study. The subjects consisted of 28 mice divided into four groups, which were negative control (Aquadest) group; positive control (0.2% of Chlorhexidine) group; 12.5% Group of mangosteen peel extract group; and 25% respec­tively. Examination of the inflammatory healing process was observed every 2 hours during 6 hours, and the inflammatory measurements of mouse gingival performed by using calipers. Data obtained was an­alyzed with the one-way ANOVA test (α=0.05) and the Tukey’s range test. Results: The results from the one-way ANOVA test and the Tukey’s range test found that there was a significant difference on the in­flammation size between the group with 12.5% of mangosteen peel extract and the group with aquadest and 0.2% of chlorhexidine. Meanwhile, the mice group with 12.5% of mangosteen peel extract and group with 25% of mangosteen peel extract did not show a significant difference in inflammatory size decrease. Conclusion: The mangosteen peel extract at the concentration of 12.5% was showing the highest anti-in­flammatory potentials since the first measurement on the second hour after treatment.


Keywords


Mangosteen (Garcinia Mangostana L.), Aquadest, Chlorhexidine, anti-inflammatory, gingival inflammation.

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References


Utami ET, Kuncoro RA, Hutami IR, Sari FT, Handajani J. Antiinflammation Effect of Skunkvine (paederia scandens) Extract in Wistar Rat. Trad Med J. 2011:16(2): p. 95–100.

Sumerti NN, Swastini IGAAP, Gejir IN. Efektivitas Berkumur Air Rebusan Kulit Buah Manggis Untuk Penyembuhan Gingivitis pada Pasien Pasca Scaling. Jurnal Skala Husada. Apr 2014;11(1): p. 41-45.

Nadiawati RP. Efek Aplikasi Gel Ekstrak Kulit Manggis (Garcinia Mangostana L.) Terhadap Kepadatan Serabut Kolagen Pada Proses Penyembuhan Luka Gingiva (Kajian Pada Rattus Norvegicus) [minor thesis]. Yogyakarta: UGM; 2013.

Setianing Y. Pengaruh Obat Kumur Ekstrak Kulit Manggis (Garcinia Mangostana L ) Terhadap Jumlah Koloni Bakteri Cairan Sulkus Gingiva Pada Pasien Gingivitis [minor thesis]. Yogyakarta: UGM; 2015.

National Institute of Health Research and Development (NIHRD). Indonesia Basic Health Research (RISKESDAS) 2007-2008. Jakarta: Ministry of Health Republic of Indonesia; 2008.

Jurnal Kedokteran Gigi [homepage on internet]. Informasi Seputar Kesehatan Gusi; c2012 [cited Nov 21 2012]; [about 5 screens]. Available from: http://www.jurnalkedokterangigi.com/post/read/483/informasi-seputar-penyakit-gusi.html

Yulia AR. Pengaruh Ekstrak Kulit Buah Manggis (Garcinia Mangostana L.) Terhadap Jumlah Fibroblas Pada Gingiva Tikus Wistar Jantan Pasca Induksi Porphyromonas Gingivalis [minor thesis]. Jember: Unej; 2013.

Arini NW, Astuti SAPD, Nahak MM. Efektivitas Kumur-Kumur Air Rebusan Kulit Buah Manggis Pasca Oral Fisioterapi Untuk Penyembuhan Gingivitis. Jurnal Skala Husada. Apr 2014;11(1): p. 6-10.

Torres-Lagares D, Gutierrez-Perez JL, Hita-Iglesias P, Magallanes-Abad N, Flores-Ruiz R, Basallote-Garcia M, et al. Randomized, Double-Blind Study Of Effectiveness Of Intra-Alveolar Application Of Chlorhexidine Gel In Reducing Incidence Of Alveolar Osteitis And Bleeding Complications In Mandibular Third Molar Surgery In Patients With Bleeding Disorders. J Oral Maxillofac Surg. Jun 2010;68(6): p. 1322-6. DOI: 10.1016/j.joms.2009.08.022.

Nakatani K, Nakahata N, Arakawa T, Yasuda H, Ohizumi Y. Inhibition of cyclooxygenase and prostaglandin E2 synthesis by gamma-mangostin, a xanthone derivative in mangosteen, in C6 rat glioma cells. Biochem Pharmacol. Jan 1, 2002;63(1): p. 73-9.

Mardawati E, Filianty F, Marta H. Kajian Aktivitas Antioksidan Ekstrak Kulit Manggis (Garcinia Mangostana L) Dalam Rangka Pemanfaatan Limbah Kulit Manggis Di Kecamatan Puspahiang Kabupaten Tasikmalaya. Jurnal Teknotan. 2008;2(3): p.

Nurchasanah. Khasiat Sakti Manggis Tumpas Berbagai Penyakit. Jakarta: Dunia Sehat; 2013. p. 84-5

Agni N. Respons Anti Inflamasi Ekstrak Kulit Buah Manggis (Garcinia Mangostana L.) Terhadap Jumlah Limfosit Pada Gingiva Tikus Wistar Jantan Pasca Diinduksi [minor thesis]. Jember: Unej; 2013.

Putri FI. Respons Antiinflamasi Ekstrak Kulit Buah Manggis (Garcinia Mangostana Linn) Terhadap Jumlah Sel Neutrofil Pada Gingiva Tikus Wistar Jantan Pasca Diinduksi Oleh Porphyromonas Gingivalis. Jurnal Kedokteran Gigi [minor thesis]. Jember: Unej; 2013.

Newman MG, Takei HH, Klokkevold PR, Carranza FA. Carranza’s Clinical Periodontology. 12th ed. Philadelphia: Saunders-Elsevier; 2014.




DOI: https://doi.org/10.24198/pjd.vol29no3.14399

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