Anti-Acne Patch Formulation Silkworm Cocoon Waste with HPMC and PVP Variations

Abstrak

Some topical preparations for acne have been developed in the form of gels and creams. However,
it is still rarely developed in the form of a patch dosage form. Waste from silkworm cocoons has the
activity of inhibiting the growth of acne-causing bacteria, can be formulated into patch preparations.
This study aims to formulate anti-acne patches from silkworm cocoon waste with variations of HPMC
and PVP. The formulation of the anti-acne patch from silkworm cocoon waste was made by mixing
the lyophilisate of silkworm cocoon waste with a patch base with variations of HPMC and PVP. The
formulations were divided into 3 with different concentrations of HPMC and PVP additives, namely
formulas 1 (4:1), 2 (2,3:1), and 3 (1:1), respectively, The evaluations carried out included organoleptic
examination, patch thickness, weight uniformity, fold resistance, moisture absorption, drying shrinkage.
The results obtained showed that the concentration of the combination of HPMC and PVP polymers
in the patch preparation gave different results from all evaluations that had been carried out, including
organoleptic evaluation, weight uniformity, fold resistance, and drying shrinkage were in accordance
with the requirements of a good patch. The optimum concentration of the combination of HPMC and
PVP as a polymer in the anti-acne patch preparation from silkworm cocoons is formula 2 with a ratio
of (2,3:1) as novelty in this study.