Indonesian Journal of Pharmaceutical Science and Technology
Piroxicam Percutaneous Permeation from Gels Through Membrane Models of Shed Snakeskin and Cellulose
Abstrak
Skin has a very important role in determining percutaneous absorption of active substance in topical administration. Study on percutaneous permeation of piroxicam from gel had been conducted using Franz Diffusion Cell with membrane model of shed snakeskin and cellulose. Piroxicam gels were made using Aqupec HV-505 base with 0; 2.5; 5; and 7.5% of DMSO as an enhancer. The results showed that the most stable gel preparation was the one with 5% DMSO (F2), so it was used for further investigation to which percutaneous permeation test. The permeation test was conducted in preparation without and with 5% DMSO (F2) in vitro through shed snakeskin and cellulose membranes. The results showed that F2 increased the permeation rate by as much as 0.0281% per minute. In comparison, the permeation rate of formulation without DMSO (F0) was 0.012% per minute. It can be concluded that DMSO can increase piroxicam penetration through shed snakeskin. Permeation study using cellulose membrane on formula F2 revealed permeation rate as much as 0.006% per minute whereas that without DMSO (F0) was 0.0112% per minute.
Keywords: DMSO, cellulose membrane, percutaneous permeation, piroxicam, shed snakeskin.
Teks Lengkap:
PDFReferensi
Dignesh, M., Ashish, D., Dinesh, R., Formulation design & development of piroxicam emulgel. Int. J. Pharm. Tec. Res., 2012, 4 (3), 1332–1344.
Curdy, C. Yogeshvar, N. Naik, A. Richard, H. Piroxicam delivery into human stratum corneum: in-vivo iontophoresis versus passive diffusion. Journal of Controlled Release, 2001; 76: 73–9
Aliberti, ALM, de Queiroz, AC, Praça, FSG, Eloy, JO, Bentley, MVLB, Medina WSG, Ketoprofen Microemulsion for Improved Skin Delivery and In Vivo Anti-inflammatory Effect AAPS PharmSciTech. 2017. Vol. 18 (7), October 2017, DOI: 10.1208/s12249-017-0749-6
Nakamura, A. Mori, D. Tojo, K. Evaluation of the Predicted Time—Concentration Profile of Serum Tulobuterol in Human after Transdermal Application. Chem. Pharm. Bull. 2012 (60), 300–305.
Hatanaka, T. Yoshida, S. Kadhum, WR. Todo, H. Sugibayashi, K. In Silico Estimation of Skin Concentration Following the Dermal Exposure to Chemicals. Pharm. Res. 2015 (32). 3965–3974.
Chakraborty, A., Devi, RKB. Rita, S. Sharatchandra, Kh. Singh, Th. I.,Preliminary studies on anti-inflammatory and analgesic activities of Spilanthes acmella in experimental animal models. Indian Journal Pharmacology, 2014, 36 (3): 148-150.
Oshizaka, T. Kikuchi, K. Kadhum, WR. Todo, H. Hatanaka, T. Wierzba, K. Sugibayashi, K. Estimation of skin concentrations of topically applied lidocaine at each depth profile. Int. J. Pharm. 2014 (475), 292–297.
Polak, S. Ghobadi, C. Mishra, H. Ahamadi, M. Patel, N. Jamei, M. Rostami-Hodjegan, A. Prediction of concentration-time profile and its inter-individual variability following the dermal drug absorption. J. Pharm. Sci. 2012 (101), 2584–2595.
Jung, EC. Maibach, H.I. Animal models for percutaneous absorption. J. Appl. Toxicol. 2015 (35), 1–10.
Shin S, Cho C, Oh I, Enhanced efficacy by percutaneous absorption of piroxicam from the poloxamer gel in rats. International Journal of Pharmaceutics. 2000 (193), 213–8.
Derry, S. Conaghan, P. Jap, D.S. Pj, W. Ra, M. Topical NSAIDs for chronic musculoskeletal pain in adults. Cochrane Database Syst. Rev. 2016
Horita, D. Hatta, I. Yoshimoto, M. Kitao, Y. Todo, H. Sugibayashi, K. Molecular mechanisms of action of different concentrations of ethanol in water on ordered structures of intercellular lipids and soft keratin in the stratum corneum. Biochim. Biophys. Acta Biomembr. 2015 (1848,) 1196–1202.
Dancik Y, Anissimov YG, Jepps OG, Roberts MS. Convective transport of highly plasma protein bound drugs facilitates direct penetration into deep tissues after topical application. Br. J. Clin. Pharmacol. 2012; 73(4):564–578.
Abd, E. Yousef, SA. Pastore, MN. Telaprolu, K. Mohammed, YH. Namjoshi, S. Grice, JE. Roberts, MS. Skin models for the testing of transdermal drugs. Clin. Pharmacol. Adv. Appl. 2016, (8), 163–176.
Oesch F, Fabian E, Guth K, Landsiedel R. Xenobiotic-metabolizing enzymes in the skin of rat, mouse, pig, guinea pig, man, and in human skin models. Arch Toxicol. 2014;88(12):2135–2190.
Uzor, PF. Mbah CJ. Omeje, EO. Perspectives on Transdermal Drug Delivery. Journal of Chemical and Pharmaceutical Research. 2011, 3(3): 680-700
Ashley, NT. Weil, Z M. Nelson, RJ. Inflammation: Mechanisms, Costs, and Natural Variation. Annu. Rev. Ecol. Evol. Syst. 2012 (43), 385–406.
Harirforoosh, S. Asghar, W. Jamali, F. Adverse effects of nonsteroidal antiinflammatory drugs: An update of gastrointestinal, cardiovascular and renal complications. J. Pharm. Pharm. Sci. 2013, (16), 821–847.
Zeng, C. Wei, J. Persson, MSM. Sarmanova, A.; Doherty, M.; Xie, D.; Wang, Y.; Li, X.; Li, J.; Long, H.; et al. Relative efficacy and safety of topical non-steroidal anti-inflammatory drugs for osteoarthritis: A systematic review and network meta-analysis of randomised controlled trials and observational studies. Br. J. Sports Med. 2018, 52, 642–650.
Tippavajhala, VK, Mendes, TO, Martin, AA, In Vivo Human Skin Penetration Study of Sunscreens by Confocal Raman Spectroscopy, AAPS PharmSciTech, Vol. 19, No. 2, February 2018 (# 2017) DOI: 10.1208/s12249-017-0852-8
Zhang J, Sun M, Fan A, Wang Z, Zhao Y. The effect of solute-membrane interaction on solute permeation under supersaturated conditions. Int J Pharm. 2013;441(1–2):389–394.
Prabhakar Panzade, P, Puranik, P, Iontophoresis: A Functional Approach for Enhancement of Transdermal Drug Delivery Asian Journal of Biomedical and Pharmaceutical Sciences 2(11) 2012, 01-08.
Jung E, Kang, YP., Yoon, I S, Kim, J S, Kwon, S W, Chung, S J, Shim, C J, Kim , D D, Effect of permeation enhancers on transdermal delivery of fluoxetine: In vitro and in vivo evaluation International Journal of Pharmaceutics, 2013, (456), 362–369
Itoh T, Xia J, Magawi R. Use of Shed Snake Skin as a Model Membrane for in Vitro Percutaneous Penetration Studies: Comparison with Human Skin [abstrak], Di dalam: Pharmaceutical Research, 1990, 7 (10), p 1042-1047. http://www.springerlink.com/content/l846g435q508k5p1/. [7 Nov 2006]
Bhasi, K. Riga, A T. and Alexander, KS. Characterization of Snake Skin by Thermoanalytical Techniques. Journal of Thermal Analysis and Calorimetry. 2004 (75), 269-276.
Lee, KE, Choi, KJ, Oh, BR, Chun, I K, Gwak, H S, Formulation and in vitro/in vivo evaluation of levodopa transdermal delivery systems, International Journal of Pharmaceutics, 2013, (456), 432–436
Agoes, G., Penelitian Difusi As.Salisilat dan Kloramfenikol dari sediaan Semisolida dengan Pembawa Vaselin, Campuran Vaselin Propilen Glikol dan Lemak Bulu domba secara In-Vitro, Acta Pharm Indonesia, 1986, 9(3), hlm 65-80
Ujwala A. Shinde, U A. Modani, S H. Singh, K H. Design and Development of Repaglinide Microemulsion Gel for Transdermal Delivery. AAPS PharmSciTech, 2018, Vol. 19(1), January 2018
British Pharmacopoiea Comissi on, British Pharmacopoiea 2016, London, TSO, 2016
Khullar, R. Kumar, D. Seth, N.,Saini, S.,Formulation and evaluation of mefenamic acid emulgel for topical delivery. Saudi Pharm. J. 2012, 20 (1), 63–67.
DOI: https://doi.org/10.24198/ijpst.v8i2.29017
Refbacks
- Saat ini tidak ada refbacks.
| Switch to English Back to Top |
| View My Stats Penerbit Universitas Padjadjaran
Jurnal ini terindeks di : Creative Commons Attribution :
Based on a work at http://jurnal.unpad.ac.id/ijpst/ |
