Cost-Effectiveness Analysis of Oral Antidiabetic Monotherapy with Metformin and Glimepiride in Diabetes Mellitus at Bahteramas Hospital

Jastria Pusmarani; Rini Apriani; Himaniarwati Himaniarwati; Julianas Baco; Azlimin Azlimin

doi:10.24198/ijpst.v12i3.63022

Cost-Effectiveness Analysis of Oral Antidiabetic Monotherapy with Metformin and Glimepiride in Diabetes Mellitus at Bahteramas Hospital

Jastria Pusmarani, Rini Apriani, Himaniarwati Himaniarwati, Julianas Baco, Azlimin Azlimin

Abstrak

Healthcare expenditure due to diabetes mellitus in Indonesia reaches approximately US$143 per person. The largest portion of this cost is attributed to medications. Therefore, ensuring the cost-efficiency and effectiveness of drug use is critically important. This study aims to determine and analyze the cost-effectiveness of antidiabetic drug therapy in patients with type 2 diabetes mellitus in the outpatient department of Bahteramas Hospital in Southeast Sulawesi Province. Descriptive methods and quantitative analysis of medical record data from Type 2 diabetes mellitus (DM) patients and treatment costs at Bahteramas Hospital in 2023. A total of 61 patients were included in the study based on the inclusion criteria. Based on the average cost-effectiveness ratio (ACER), glimepiride was more efficient, with a value of IDR 18,389, compared to metformin, which had an ACER of IDR 25,405. However, based on the incremental cost-effectiveness ratio (ICER), metformin was more cost-effective, with a value of IDR 50,070. While the biguanide group (metformin) appears more cost-effective than the sulfonylurea group (glimepiride) based on ICER, the overall findings indicate that, based on ACER, glimepiride (sulfonylurea) is more cost-effective. Therefore, glimepiride can be recommended as a single oral antidiabetic therapy at Bahteramas Hospital.

Kata Kunci

Bahteramas Hospital; Cost; Diabetes Mellitus; Effectiveness

Teks Lengkap:

PDF

Referensi

Perkumpulan Endokrinologi Indonesia. Pedoman Pengelolaan dan pencegahan diabetes melitus tipe 2 di Indonesia. Jakarta: PB Perkeni; 2021.

Ramadhani NF, Siregar KN, Adrian V, Sari IR, Hikmahrachim HG. Hubungan Aktivitas Fisik dengan Diabetes Melitus pada Wanita Usia 20-25 di DKI Jakarta (Analisis Data Posbindu PTM 2019). Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan. 2022;2(2):1.

Magliano DJ, Boyko EJ; IDF Diabetes Atlas 10th Edition Scientific Committee. IDF Diabetes Atlas [Internet]. 10th ed. Brussels: International Diabetes Federation; 2021. Available from: https://www.ncbi.nlm.nih.gov/books/NBK581934/

IDF Diabetes Atlas 7th Edition Scientific Committee. IDF Diabetes Atlas [Internet]. 7th ed. Brussels: International Diabetes Federation; 2015. Available from: https://diabetesatlas.org/resources/previous-editions/

Kemenkes RI. Pedoman Penerapan Kajian Farmakoekonomi. Jakarta: Kementerian Kesehatan Republik Indonesia; 2013.

Arini HD, Kurnianta PDM. Tinjauan Komparatif Studi Mengenai Efektivitas Biaya Antidiabetes Oral pada Diabetes Melitus Tipe 2. Acta Holistica Pharmaciana. 2019;1(2):6–17.

Jannah EN, Ismunandar A, Maulana LH. Analisis Efektivitas Biaya Penggunaan Antidiabetik Oral pada Pasien Diabetes Mellitus Tipe 2 Rawat Jalan Peserta BPJS di RSUD Bumiayu 2020: Array. Pharmacy Peradaban Journal. 2021;1(2):20-9.

Restinia M, Anggriani Y, Kusumaeni T, Meryta A. Profil Pengobatan Pasien Rawat Jalan Diabetes Melitus Tipe 2 setelah Pelaksanaan JKN. Jurnal Ilmu Kefarmasian Indonesia. 2015;13(1):63-8.

Anggriani Y. Evaluasi Biaya Pengobatan Pada Pasien Diabetes Melitus Tipe 2 Rawat Jalan dengan Terapi Insulin di RSUP X di Jakarta Periode Januari 2016-Desember 2017. Pharmaceutical Journal of Indonesia. 2019;4(2):91-7.

Pambagyanik AA, Lorensia A, Rahem A. Analisis Cost-Effectiveness Pengobatan Pada Pasien Diabetes Mellitus Tipe 2 Rawat Jalan Di RSUD dr. R. Koesma Kabupaten Tuban. Media Pharmaceutica Indonesiana (MPI). 2023;4(4): 107-16.

Sirait BI. Sindroma Ovarium Polikistik dan Infertilitas. Jurnal Ilmiah WIDYA. 2019;5(3):1–5.

Zihan Z, Rodiani, Fakhruddin H. Pengaruh metformin terhadap wanita infertilitas dengan sindrom polikistik ovarium. Majority. 2019;8(1): 172-7.

Rahmawati F, Natosba J, Jaji J. Skrining diabetes mellitus gestasional dan faktor risiko yang mempengaruhinya. Jurnal Keperawatan Sriwijaya. 2016;3(2):33–43.

Hayatullah MM, Hafizzurachman H. Konfirmasi Lima Faktor yang Berpengaruh terhadap Pencegahan Diabetes Mellitus Pada Ibu Hamil. Jurnal Ilmiah Kesehatan. 2020;19(01):15–23.

Dewi FP. Analisis Efektivitas Biaya Pengobatan Diabetes Melitus Tipe 2 Pada Pasien Rawat Jalan Di RSUD Dr. Moewardi Tahun 2018. Universitas Muhammadiyah Surakarta; 2019.

Ekasari E, Dhanny DR. Faktor Yang Mempengaruhi Kadar Glukosa Darah Penderita Diabetes Melitus Tipe Ii Usia 46-65 Tahun Di Kabupaten Wakatobi. Journal of Nutrition College. 2022;11(2):154–62.

Sharma S, Singh H, Ahmad N, Mishra P, Tiwari A. The role of melatonin in diabetes: therapeutic implications. Archives of Endocrinology and Metabolism. 2015;59(5):391–9.

Fatimah RN. Diabetes melitus tipe 2. Jurnal Majority. 2015;4(5):93–101.

Kuswandi KPP, Acang N, PD S. Hubungan Jenis Kelamin Pada Pasien Hiperurisemia Yang Menderita Diabetes Melitus Tipe 2 Di Puskesmas Cihaurbeuti Tahun 2022. In: Bandung Conference Series: Medical Science. 2024.

Indarto I, Widiyanto A, Atmojo JT. Efektivitas Metformin dalam Penurunan Kadar Glukosa pada Pasien Diabetes Mellitus Tipe-2: Meta-Analisis. Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal. 2023;13(2):621–30.

Luo P, Qiu L, Liu Y, Liu X lan, Zheng J ling, Xue H ying, et al. Metformin treatment was associated with decreased mortality in COVID-19 patients with diabetes in a retrospective analysis. The American journal of tropical medicine and hygiene. 2020;103(1):69.

Meliawati NW. Cost-Effectiveness Analysis Of The Use Of Metformin And Glimepiride In Patients With Type 2 Diabetes Mellitus Inpatient At The Hospital. Robert Wolter Mongisidi Manado City. Jurnal Farmasi Medica. 2023;6(1): 68–76.

Widya NC. Analisis Efektivitas Biaya (Cost Effectiveness Analysis) Penggunaan Kombinasi Insulin pada Pasien Diabetes Mellitus Tipe 2 yang Menjalani Rawat Inap di RSUD Mardi Waluyo Kota Blitar Periode 2019–2020. Stikes Karya Putra Bangsa Tulungagung; 2021.

Nurmainah N, Syabriyantini S, Susanti R. Efektivitas Biaya Penggunaan Ampisilin Dansefotaksim Pada Pasien Anak Demam Tifoid. Media Kesehatan Masyarakat Indonesia. 2017; 13(2): 131-8.

DOI: https://doi.org/10.24198/ijpst.v12i3.63022